Welcome to The Center for Translational Biomedical Research


Tan X, Xie G, Sun X, Li Q, Zhong W, Qiao P, Sun X, Jia W, Zhou Z. High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways. PLoS One. 2013 Apr 23;8(4):e61409. doi:10.1371/journal.pone.0061409. Print 2013. PubMed PMID: 23626681; PubMed Central PMCID: PMC3634078.

Li Q, Zhong W, Qiu Y, Kang X, Sun X, Tan X, Zhao Y, Sun X, Jia W, Zhou Z.Preservation of hepatocyte nuclear factor-4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats. Alcohol Clin Exp Res. 2013 Apr;37(4):587-98. doi:10.1111/acer.12013. Epub 2012 Nov 5. PubMed PMID: 23126616; PubMed Central PMCID:PMC3618617.

Tan X, Sun X, Li Q, Zhao Y, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z. Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease inmice. Am J Pathol. 2012 Oct;181(4):1279-86. doi: 10.1016/j.ajpath.2012.06.013. Epub 2012 Jul 27. PubMed PMID: 22841822; PubMed Central PMCID: PMC3463622.

Sun X, Tang Y, Tan X, Li Q, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z. Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice.Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G548-57. doi:10.1152/ajpgi.00342.2011. Epub 2011 Dec 15. PubMed PMID: 22173916; PubMed Central PMCID: PMC3311430.

Zhong W, Zhao Y, Tang Y, Wei X, Shi X, Sun W, Sun X, Yin X, Sun X, Kim S, McClain CJ, Zhang X, Zhou Z. Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis. Am J Pathol. 2012 Mar;180(3):998-1007. doi:10.1016/j.ajpath.2011.11.017. Epub 2012 Jan 9. PubMed PMID: 22234172; PubMed Central PMCID: PMC3349880.

Zhao Y, Zhong W, Sun X, Song Z, Clemens DL, Kang YJ, McClain CJ, Zhou Z. Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodentsvia an epigenetic mechanism. Am J Pathol. 2011 Aug;179(2):693-702. doi: 10.1016/j.ajpath.2011.04.006. Epub 2011 Jun 2. PubMed PMID: 21708112; PubMed Central PMCID: PMC3157256

Sun X, Luo W, Tan X, Li Q, Zhao Y, Zhong W, Sun X, Brouwer C, Zhou Z. Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 10. [Epub ahead of print] PMID:24113770 [PubMed - as supplied by publisher]

Zhong W, Li Q, Xie G, Sun X, Tan X, Sun X, Jia W, Zhou Z. Dietary fat sources differentially modulate intestinal barrier and hepatic inflammation in alcohol-induced liver injury in rats. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 10. [Epub ahead of print]

Zhong W, Zhao Y, McClain CJ, Kang YJ, Zhou Z. Inactivation of hepatocyte nuclear factor-4a mediates alcoholinduced down-regulation of intestinal tight junction proteins. Am J Physiol. 2010; 299:G643-G651

Zhong W, McClain CJ, Cave M, Kang YJ, Zhou Z. The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol. 2010; G625-633.

Kang X, Zhong W, Liu J, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4a and peroxisome proliferators activated receptor-a. Hepatology 2009; 50:1241-1250.

Xie, G., Zheng, X., Qi, X., Cao, Y., Chi, Y., Su, M., Ni, Y., Qiu, Y., Liu, Y., Li, H., Zhao, A., Jia, W.* Metabonomic evaluation of Melamine-induced acute renal toxicity in rats. Journal of Proteome Research (IF = 5.675), Epub ahead of print (DOI: 10.1021/pr900333h), 2009.

Bao, Y., Zhao, T., Wang, X., Qiu, Y., Su, M., Jia, W.* Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers, Journal of Proteome Research (IF = 5.675), 8(4), 1623-1630, 2009.

Zhao, T., Chen, T., Qiu, Y., Zou, X., Li, X., Su, M., Yan, C., Zhao, A., Jia, W.* Trace element profiling using inductively coupled plasma mass spectrometry and its application in an osteoarthritis study, Analytical Chemistry (IF = 5.287), 81(9), 3683-3692, 2009.

Wang, X., Zhao, T., Qiu, Y., Su, M., Jiang, T., Zhou, M., Zhao, A., Jia, W.*Metabonomics approach to understanding acute and chronic stress in rat models, Journal of Proteome Research, 8(5), 2511-2518, 2009.

Xie, G., Ye, M., Wang, Y., Ni, Y., Su, M., Huang, H., Qiu, M., Zhao, A., Zheng, X., Chen, T., Jia, W.* Characterization of Pu-erh tea using chemical and metabolic profiling approaches, Journal of Agricultural and Food Chemistry, 57, 3046-3054, 2009.

Li, H., Dai, M., Jia, W. Paeonol attenuates high-fat-induced atherosclerosis in rabbits by anti-inflammatory
activity, Planta Medica, 75(1), 7-11, 2009.

Dan, M., Xie, G., Gao, X., Long, X., Su, M., Zhao, A., Zhao, T., Zhou, M., Qiu, Y., Jia, W.* A rapid ultra-performance liquid chromatography – electrospray ionization mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng, Phytochemical Analysis, 20 (1), 68-76, 2009.

Li, H., Xie, Z., Lin, J., Song, H., Wang, Q., Wang, K., Su, M., Qiu, Y., Zhao, T., Song, K., Wang, X., Zhou, M., Liu, P., Zhao, G., Zhang, Q., Jia, W.* Transcriptomic and metabonomic profiling of obesity-Prone and obesity-resistant rats under high fat diet, Journal of Proteome Research, 7(11), 4775-4783, 2008.

Jia, W.,* Li, H., Zhao, L., Nicholson, J., Gut microbiota: a potential new territory for drug targeting, Nature Reviews Drug Discovery (IF = 23.31), Vol 7, 123-131, 2008.

Shen, Q., Li, X., Qiu, Y., Su, M., Liu, Y., Li, H., Wang, X., Zou, X., Yan, C., Yu, L., Li, S., Wan, C., He, L., Jia, W.* Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats, Journal of Proteome Research, 7(5), 2151-2157, 2008.

Ni, N., Su, M., Lin, J., Wang, X., Qiu, Y., Zhao, A., Chen, T., Jia, W.* Metabolic profiling reveals disorder of amino acid metabolism in various brain regions from a rat model of chronic unpredictable mild stress, FEBS Letters, Vol. 582 (17), 2627-2636, 2008.

Li, M., Wang, B., Zhang, M., Rantlainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., Wei , H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia, W., Xiao, C., Smith, L., Holmes, E., Tang, H., Zhao, G., Yang, S., Nicholson, J. K., Li, L., Zhao, L., Symbiotic gut microbes modulate human metabolic phenotypes, P NATL ACAD SCI USA, (IF = 9.643), 105, 6, 2117-2122, 2008.

Xie, G., Plumb, R., Su, M., Xu, Z., Zhao, A., Qiu, Q., Long, X., Liu, Z. Jia, W.* Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research, Journal of Separation Science, 31, 1015-1026, 2008.

Lin, J., Su, M., Wang, X., Qiu, Y., Hao, J., Long, X., Zhou, M., Yan, C., Jia, W.*Comprehensive Profiling of Hydrophilic Metabolites in Rat Brain Tissues Using Gas Chromatography/Mass Spectrometry, Journal of Separation Science, 31: 2831-2838, 2008.

Tao, X., Liu, Y., Qiu, Y., Lin, J., Zhao, A., Su, M., Jia, W.* GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia, Analytical and Bioanalytical Chemistry, 391: 2881-288, 2008.

Chen, M., Ni, Y., Duan, H., Qiu, Y., Guo, C., Jiao, Y., Shi, H., Su, M., Jia, W.* Mass Spectrometry-based Metabolic Profiling of Rat Urine Associated with General Toxicity Induced by Multiglycoside of Tripterygium Wilfordii Hook. F., Chemical Research in Toxicology, 21: 288-294, 2008.

Xie, G., Ni, Y., Su, M., Zhang, Y., Zhao, A., Gao, X., Liu, Z., Long, X., Jia, W.*Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs, Metabolomics, 4: 248-260, 2008. Dan, M., Su, M., Gao, X., Zhao, T., Zhao, A., Xie, G., Qiu, Y., Zhou, M., Liu, Z., Jia, W.* Metabolite profiling of Panax notoginseng using UPLC-ESI-MS,Phytochemistry, 69, 2237-2244, 2008.

Gao, X., Dan, M., Zhao, A., Xie, G., Jia, W.* Simultaneous analysis of nine saponins in flower buds of Panax notoginseng using high performance liquid chromatography, Biomedical Chromatography, 22: 244-249, 2008.